Great Dane Puppies for Sale in South Carolina, USA
PuppyFinder.com is your source for finding an ideal Great Dane Puppy for Sale in South Carolina, USA area.
- Great Danes are susceptible to heatstroke due to their size and can overheat quickly in South Carolina's humid summers. Provide plenty of shade, cool water, and limit strenuous outdoor activity during the hottest parts of the day, especially in cities like Columbia which experiences significant heat.
- Regular, low-impact exercise is key. While not high-energy, Danes need walks to maintain their health and prevent obesity. Enjoy leisurely strolls along the coast in Charleston or through greener parks in Greenville, but always be mindful of the heat.
- Their short coat requires minimal grooming, but regular brushing helps reduce shedding. In South Carolina's climate, focus on keeping their living spaces cool and comfortable indoors, as they are prone to seeking air-conditioned havens.
Great Dane puppies are in high demand in South Carolina area. Although there are no direct matches today, please see available puppies below or explore popular Great Dane mixes and other similar dog breeds.
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Great Dane Puppies Available Outside Your Current Filters
AKC European Blood Line Great Dane puppies
$1,000
Litter of 12
Great Dane
Male(s) and Female(s), 4 Months Old
USA WAKARUSA, IN, USA
Date listed: 07/19/2026
For more information please call 574-862-2208 anytime Monday - Saturday. AKC Registration, 100% Euro Champion Bloodlines, 2 year health guarantee, microchipped. Crate, leash and...
AKC Black Great Dane Maxi
$1,000
Maxi
Great Dane
Female, 10 Weeks Old
USA WILLIS, TX, USA
Date listed: 08/04/2026
Mom - Blue with white markings(140#) Dad - Black with White Markings (170#)
AKC Black Great Dane Flo
$1,000
Flo
Great Dane
Female, 10 Weeks Old
USA WILLIS, TX, USA
Date listed: 08/04/2026
Mom - Blue with white markings(140#) Dad - Black with White Markings (170#)
Emmett
$1,050
Emmett
Great Dane
Male, 14 Weeks Old
USA MIDDLEBURY, IN, USA
Date listed: 09/21/2026
This adorable litter was born on June 27. They are AKC registered and will be vet checked and microchipped. They will have their first puppy vaccinations and dewormings given as...
Great Dane litter just in time for holidays
$500
Litter of 3
Great Dane
Male(s) and Female(s), 3 Weeks Old
USA MAYSVILLE, KY, USA
Date listed: 09/25/2026
Our Millie just had a litter of 6 pups. 3 have already been selected for their forever homes. The remaining 3 are available and will be homed November 4th. They will have their...
Great Dane Puppies
$1,500
Litter of 6
Great Dane
Male(s) and Female(s), 4 Months Old
USA TEMECULA, CA, USA
Date listed: 07/10/2026
We have 6 Great Danes looking for their forever homes. 3 are boys 3 are girls. Mom is papered, dad is not. Both parents are sweet and loving as most Danes are. Mom is a blue dane...
CKC Great Dane Puppies We are Real People
$1,100
Litter of 9
Great Dane
Male(s) and Female(s), 12 Weeks Old
USA SPRAGGS, PA, USA
Date listed: 10/05/2026
Our beautiful pups are chock full of personality and eager to give kisses to their new families. 724-435-7912 landline 724-710-5892. text We are an hour below Pittsburgh PA....
AKC Great Dane Litter
$1,000
Litter of 8
Great Dane
Male, 11 Weeks Old
USA WILLIS, TX, USA
Date listed: 08/04/2026
We currently have 4 AKC Great Dane Male Puppies. They will be ready for their forever homes around September 15th. We have harlequins, merles, and a solid black with white...
CKC Great Dane Puppies
$1,800
Litter of 5
Great Dane
Male(s) and Female(s), 5 Weeks Old
USA GASTONIA, NC, USA
Date listed: 09/17/2026
CKC Registered. RTG 10/23/2026. Puppies are changing daily and more photos or facetime calls are available by request. Puppies are 25% European and it is showing in his body...
AKC Black Great Dane Pearl
$1,000
Pearl
Great Dane
Female, 10 Weeks Old
USA WILLIS, TX, USA
Date listed: 08/04/2026
Mom - Blue with white markings(140#) Dad - Black with White Markings (170#)
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